Quoted specs are (blatantly plagerized from MS's post):
I'm running on an ancient Mac and in my PC mode I'm speccing:System Requirements
* OS: Windows XP SP2 / Windows Vista / Windows 7 (32 or 64-bit)
* CPU: Intel Core 2 Duo 1.8 Ghz or AMD Athlon X2 3800+
* Memory: 1GB RAM
* Video: NVIDIA GeForce 7950 / ATI Radeon X1800 / Intel HD Graphics
* Sound: DirectX 9.0c Compatible Soundcard
* DirectX: Version 9.0c or Higher
* HDD: 8GB Free Disk Space
* Network: Internet Broadband Connection Required
* Disc: 6X DVD-ROM
Recommended System Configuration
* OS: Windows XP SP2 / Windows Vista / Windows 7 (32 or 64-bit)
* CPU: Intel E8400 Core 2 Duo or AMD Athlon X2 5600+
* Memory: 2GB RAM+
* Video: NVIDIA GeForce 8800 / ATI Radeon HD 3850+
* Sound: DirectX 9.0c Compatible Soundcard
* DirectX: Version 9.0c or Higher
* HDD: 8GB Free Disk Space
* Network: Internet Broadband Connection Required
* Disc: 6X DVD-ROM
Source: http://www.startrekonline.com/node/494
2.18 Intel Duo core
2gigs RAM
Radeon X1600 with 128Meg onboard
Windows XP, SP2
I can get up to 1440x900 resolution but have to keep the graphics parameters off the highest settings. Toned down one notch, they're still very acceptable with framerate quite good and lag at minimum (if at all). With resolution set at 1200x800 all is ducky. Only problem I've encountered is entering into a player saturated area (can anyone say 'the auction house at Ironforge?'). Saying that, its pretty much the same specs I was running with WoW and WHO, all is better than acceptable.